Gene expression - California Lutheran University

Gene expression - California Lutheran University

Gene expression Chapter 15 Genes and Development

Central dogma

1956 version of Central dogma by Francis Crick

Central dogma

1958 version of Central dogma

Genetic code

Genetic code

Transcription

Pase DNA

RNA polymerase-3D at Online Macromolecular Museum

Transcription

Transcription

RNA polymerase-3D at Online Macromolecular Museum

Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

E1

I1

E2 I2

E3

DNA template

Transcription

I3 E4

I4

Exons

Introns

5 cap 3 poly-A tail

Primary RNA transcript

Introns are removed 5 cap

Mature mRNA

3 poly-A tail

Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

E1

I1

E2 I2

E3

I3

DNA template

E4

I4

Exons Introns

Transcription

5 cap 3 poly-A tail

Primary RNA transcript

Introns are removed 3 poly-A tail

5 cap

a. Mature mRNA

Intron 1

mRNA 3

2

4 DNA

7

5

6 Exon

b.

c. b: Courtesy of Dr. Bert OMalley, Baylor College of Medicine

Translation

Genetic code

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