History of Neurology

History of Neurology

History of Neurology WALTER B. CANNON SYMPATHETIC NERVOUS SYSTEM & STRESS RICHARD J. BAROHN, MD GERTRUDE AND DEWEY ZIEGLER PROFESSOR OF NEUROLOGY THE UNIVERSITY OF KANSAS MEDICAL CENTER Walter B. Cannon MD 18711945 Born: Prairie du Chien, Wisconsin Harvard Med School-1896-1900 Instructor in Physiology at HMS Mentor Henry Pickering Bowditch who trained under Claude Bernard

1906-Professor and Chairman of the Department of Physiology Till 1942 Initial research: used newly discovered x-rays to study mechanisms of swallowing & stomach motility 1st paper- Digestion in the Goose (1898) In 1945 Cannon summarized his career in physiology by describing his focus at different ages: Age 26 40: digestion and the bismuth meal Age 40 46: bodily effects of emotional excitement Age 46 51: wound shock investigations Age 51 59: stable states of the organism Age 59 68: chemical mediation of nerve impulses (collaboration with Arturo Rosenblueth) Age 68 + : chemical sensitivity of nerve-isolated organs He said If I had not undertaken research on the physiology of the digestive tract by use of the newly discovered X-rays, I would have become a neurologist.

Walter B. Cannon MD Autonomic Nervous System 1912- Observed movements of gut stopped experimental animals were Prior automatic research by Gaskill/Langley showed origins distribution & local effects of autonomic neurons Some Aspects of Animals Surviving Over 20 years he & team published many papers on howComplete Exclusion of Sympathetic under physiologic stress the sympathetic NS & adrenal Nerve medulla act to produce visceral adjustment that are needed for preservation Also researched on central mechanisms Involved in emotional behavior & emotional experience. Emergency theory of sympatho-adrenal system:

1929 experiment reviewed chains of ganglia in cats when stressed showed physiologic deficiencies Coined term homeostasis-steady state of internal milieu Demonstrated heart affected by product secreted by adrenal medulla- sympathetic Amer. J. Physiol, 1929, 89:51-107 Walter B. Cannon MD: Publications for Lay Public 1915 Bodily Changes in Pain, Hunger, Fear

and Rage "Voodoo" Death 1942 The Wisdom of the Body 1932 Digestion and Health 1936 The Way of an Investigator 1945 VOODOO Death Walter Cannon .

American Anthropologist, 44. 1942. 169181 Advice to Young Investigators From Successful, Wise Scientists Over Last 150 Years Claude Bernard An Introduction to the Study of Experimental Medicine (1865) Santiago Ramon y Cajal Advice for A Young Investigator (1916; 1999 English translation) Walter Cannon The Way of an Investigator: A scientists experiences in medical research (1945) Edward O. Wilson Letters to a Young Scientist (2013) The Way of an Investigator: A scientists experiences in medical research (1945)

Walter Cannon Chapter III: Fitness For The Enterprise As the years have gone by, I have been more and more impressed by the occasional lack of one or another of the essential qualities in a man, that spoils his otherwise excellent equipment in mind and character. As an investigator he may, for example, be rich in suggestive ideas and yet be indolent and therefore sterile; he may be a hard worker but secretive about his results and suspicious of his fellow workers, so that his is despised by them; he may be an earnest experimenter but inconsiderate of his helpers, and therefore he may find that help is begrudged him; or he may be prone to display an attitude of superiority and consequently be subjected to derision, expressed or silent. Sometimes an investigators excellence in important regards is so great that it overbalances his defects. I have heard of an eminent scientist who, after weeks of intense and exhausting labor on a difficult problem, would break away in a disgraceful carouse. His escapades ere tolerated because of his

outstanding discoveries. Clearly such need for balancing good and evil is not to be looked upon with any enthusiasm. It is better to strive for a set of qualities that can consistently exist in one anothers companionship and that together favor effectiveness. The Way of an Investigator . Pitch for Nobel?

Recently Viewed Presentations

  • Conflicts of Interest - IN.gov

    Conflicts of Interest - IN.gov

    Tess Benham has no conflicts of interest to disclose. Dr. Denise Fields is an employee of Express Scripts, but this will not influence today's presentation. Master Trooper Tamara Watson has no conflicts of interest to disclose
  • 15 JIT and Lean Operations McGraw-Hill/Irwin Copyright  2007

    15 JIT and Lean Operations McGraw-Hill/Irwin Copyright 2007

    Achieves a smooth, rapid flow of materials through the system Summary JIT Goals and Building Blocks Supporting Goals Eliminate disruptions Make system flexible Eliminate waste, especially excess inventory Sources of Waste Overproduction Waiting time Unnecessary transportation Processing waste Inefficient work...
  • Anatomy, Physiology, and Disease

    Anatomy, Physiology, and Disease

    Decubitis Ulcer. Etiology: tissue injury from unrelieved pressure upon a specific area. S/S: red, inflamed, crater-like lesion usually located over bony prominence. DX: visual inspection, culturing of site for infection. TX: preventative measures such as turning and padding important; treat...
  • v-l-e.com

    v-l-e.com

    Moodle How a VLE can save you time and lower your stress level Failing to What? In 2003, KES closed for 6 weeks due to a very real terrorist threat Other risks exist: Bird Flu Flooding How would you teach...
  • An Inverse Compton Scattering (ICS) Source for High-Energy,

    An Inverse Compton Scattering (ICS) Source for High-Energy,

    Experimental Challenge. ERL Workshop. What experimenters want: 50-100 keV x-rays for penetration through several mm of metal. Sub 1 ┬Ám spot (needs to be smaller than typical grain size)
  • Unit 2 - Centennial School District

    Unit 2 - Centennial School District

    The atom is the smallest basic unit of matter. Atoms are very small. Smallest components of an element that retains its properties. Elements are made of countless atoms of the element. Each atom has the same properties as the element....
  • Compare SHARC 2000 Workshop -- Coding highly parallel ...

    Compare SHARC 2000 Workshop -- Coding highly parallel ...

    This presentation will probably involve audience discussion, which will create action items. Use PowerPoint to keep track of these action items during your presentation
  • Main Ideas: Stated and Implied - Imperial Valley College

    Main Ideas: Stated and Implied - Imperial Valley College

    Stated Main Ideas. Stated main ideas will be in the topic sentence. Topic sentences may be at the beginning, middle, or end of the paragraph, but are usuallyat the beginning. The focus of the paragraph. A general statement that covers...