ii. Inflammation Antibodies and immune complexes may deposit in tissues or blood vessels, and elicit an acute inflammatory reaction by activating complement, or by engaging Fc receptors of leukocytes. The inflammatory reaction causes tissue
injury.e.g. Goodpasture syndrome and pemphigus vulgaris Inflammation iii. Antibody-mediated cellular
dysfunction. Antibodies can bind to cell surface receptors or essential molecules, and cause functional derangements either inhibition( e.g myasthenia Gravis), or unregulated activation( e.g. Graves disease )
without cell injury. Antibody-mediated cellular .dysfunction Immune Complex Diseases.3 :(Type III Hypersensitivity)
are caused by antibodies binding to antigens to form complexes that circulate and deposit in vascular beds and stimulate inflammation, typically as a consequence of complement activation. -
The antigens in these complexes may be exogenous antigens, such as microbial proteins, or endogenous antigens, such as nucleoproteins Immune complexmediated
disease can be either :systemic or local A.Systemic Immune Complex Disease complexes are formed in the circulation and are deposited in
several organs. E.g. -Acute serum sickness : inoculation of a large volume of exogenous antigen -Systemic lupus erythematosus.
-polyarteritis nodosa (response to infectious agents) The pathogenesis of systemic immune complex disease can be divided into three phases: (1) formation of antigen antibody
complexes in the circulation . (2) deposition of the immune complexes in various tissues. (3) an inflammatory reaction in various sites throughout the body. -
The antibody classes that induce such lesions are complement-fixing antibodies (i.e., IgG and IgM) .- Single large antigen exposures tend to induce acute, self-limited disease that
resolves as the antigen is eliminated (e.g.,poststreptococcal ; glomerulonephritis) repeated or prolonged exposure leads to chronic, recurrent tissue .injury (e.g.SLE )
-Histopathologic Lesions : Inflammation, necrotizing vasculitis (fibrinoid necrosis) B. Local Immune Complex :Disease -The complexes are formed and
deposited in a specific site. Local immune complex disease is characterized by a localized tissue vasculitis and necrosis. A model of local immune complex diseases is the Arthus
Reaction(Intracutaneous antigen injection in previously sensitized hosts carrying the appropriate circulating antibody). CellMediated (Type IV) . 4 : Hypersensitivity
T cellmediated (type IV) hypersensitivity is mediated by antigen specific T lymphocytes and includes delayed-type hypersensitivity (CD4+ T) cells and T cellmediated cytotoxicity (CD8+ T) cells.
A-Reactions of CD4+ T cells : delayed-type hypersensitivity and immune inflammation : This response is largely mediated by helper CD4+ T cells and can be of two major types;
responses associated with TH1 CD4+ T cells are predominated by macrophages, while those driven by TH 17 cells are characterized by a greater neutrophil infiltration. The classic delayed-type
hypersensitivity (DTH) response is the tuberculin reaction to intracutaneous injection of purified protein derivative (PPD) derived from . the tubercle bacillus Prior tuberculosis infection results in
circulating PPD-responsive memory CD4+T cells; subsequent PPD injection into such an individual leads to the recruitment and activation of these cells beginning at 6 to 8 hours and peaking at 24 to 72 hours (the .delayed in DTH)
Granulomatous inflammation occurs when persistent or nondegradable antigens (e.g., foreign bodies) lead to chronic macrophage activation manifesting as large
epithelioid cells; nodules of these activated cells are called granulomas. Granulomatous inflammation Contact dermatitis; multiple
sclerosis; type 1 diabetes; tuberculosis are examples of a DTH response B-Reactions of CD8+ T cells: cell-mediated Class
I MHC molecules bind to intracellular :cytotoxicity peptide antigens and present the peptides to CD8+ T lymphocytes, stimulating the differentiation of these T cells into effector cells called cytotoxic Tcell( CTLs) .
CTLs play a critical role in resistance to virus infections and some tumors and allograft rejection AUTOIMMUNE DISEASES Autoimmunity: Immune reactions to
self antigens Autoimmune diseases range from those in which specific immune responses are directed against one particular
organ or cell type and result in localized tissue , damage to multisystem diseases characterized by lesions in many organs and associated
with multiple autoantibodies or T cellmediated reactions against numerous self .antigens Autoimmune Diseases
In many of the systemic diseases that are caused by immune complexes and autoantibodies, the lesions affect principally the connective tissue and blood vessels of the various organs . involved
Therefore, these diseases are often referred to as collagen vascular or connective tissue disorders, even though the immunologic reactions are not specifically directed against constituents of connective tissue or blood .vessels
Normal persons are unresponsive (tolerant) to their own (self) antigens, and autoimmunity results from a failure of self.tolerance - Self tolerance:
refers to a lack of immune responsiveness ones own tissue antigens. Immunologic tolerance Central Tolerance :
This refers to the process by which T and B cells that recognize self antigens are either killed (negative selection) or rendered harmless during their maturation in central (generative) lymphoid organs (i.e., in the thymus for T cells and in the bone marrow for B cells).
Peripheral Tolerance Self reactive cells that escape central regulatory mechanisms can be removed or inactivated in the periphery through one of the following pathways:
1.Anergy: This term refers to functional inactivation (rather than death) of lymphocytes induced by encounter with antigens under certain conditions. 2. suppression by regulatory T lymphocytes,
3. Activation-induced cell death ( apoptosis). Mechanisms of Autoimmunity: It is believed that the breakdown of selftolerance and development of autoimmunity result from a
combination of inherited susceptibility genes, which influence lymphocyte tolerance, and environmental factors, such as infections or tissue injury, that alter the display of self antigens
Pathogenesis of auroimmune disaeses :Genetic Factors in Autoimmunity.1 -Autoimmune diseases have a tendency to run in families. -Several autoimmune diseases are
linked with the HLA locus, especially class II alleles (HLA-DR, -DQ) e.g. - Rheumatoid arthritis and HLA DRB1 -Ankylosing spondylitis and HLAB*27 -many genetic polymorphisms in ( non HLA Genes) are associated with different autoimmune diseases.
e.g. PTPN-22 gene and type I diabetes and rheumatoid arthritis. Role of Infections and Tissue .2 Injury Microbes may induce autoimmune reactions by
several mechanisms: -Viruses and other microbes may share crossreacting epitopes with self antigens,This phenomenon is called molecular mimicry. . Microbial infections with resultant tissue necrosis and inflammation can expose selfantigens and activate APCs and lymphocytes in the tissues.
Autoimmune diseases are , more .common in women than in men Tha nk
Local Bridge Replacement Program. The Local Bridge Replacement Program is funded from the Minnesota State Transportation Fund. State Transportation Fund (Bridge Bonds) is one of three funding programs exclusively for local bridge projects that the State Aid Division administers.
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