What is the role of the pentose phosphate

What is the role of the pentose phosphate

What is the role of the pentose phosphate pathway? Eric Niederhoffer SIU-SOM Overview NADPH production Glutathione reduction (E), fatty acid/cholesterol synthesis (L) Glycolytic intermediates Fructose-6-phosphate, glyceraldehyde-3-phosphate Ribose-5-phosphate Nucleotide synthesis (nucleated cells) Glycolysis and Pentose Phosphate HO GSH Pathways GP HK 2 Glc

G6P PGI Glycolysis PFK aldolase DHAP + NADP+ + H+ GR F6P NADPH F16BP G3P G3PDH 1,3-BPG

PGK 3PG 2PG G6PDH lactonase 6PGDH CO2 6PG PPP PGM enolase PEP PK Pyr

2 3-7 C metabolites (R5P, F6P, G3P) H2O GSSG Oxidative Phase HK Glucose G6P PGI F6P NADP+ NADPH G6PDH

6PGL lactonase FA/cholesterol synthesis RBC ox stress 6PG 6PGDH CO2 Ru5P NADP+ NADPH Non-oxidative Phase Ru5P RuP3E F6P G3P Glycolysis Xu5P

TK E4P F6P R5PI S7P TA G3P R5P Nucleotides TK Review Questions What are the main functions of the pentose phosphate pathway? Which enzymes produce NADPH? Which intermediates can feed back into the glycolytic pathway?

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