Overview of epidemiologic studies on naproxen acute MI

Overview of epidemiologic studies on naproxen acute MI

Overview of epidemiologic studies
on naproxen acute MI risk
Study

Population

Design

Reference
group

Naproxen
cases

Ray

Medicaid

Cohort

Nonuse

201

Graham

HMO

Nested case control

Remote

367

Rodriguez

GPRD

Nested case control

Nonuse

49

Rahme

Quebec

Nested case control

Other
NSAIDS

397

Mamdani

Ontario

Cohort

Nonuse

15

Schlienger

GPRD

Nested case control

Nonuse

19

Kimmel

Community

Case control

Remote

?

Solomon

Medicaid/
Medicare

Case control

Remote

?

Watson

GPRD

Nested case control

Nonuse

26

Ingenix

MCO

Cohort

Ibuprofen/
diclofenac

179

GPRD=General Practice Research Database
MCO=managed care organization

FDA committees say it's time to raise the bar on NSAID
trials [Rheumawire > News; Mar 9, 2005]

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