Methods in Cochrane Reviews: a chose-andpick model versus
Methods in Cochrane Reviews: a chose-andpick model versus a structured model Cochrane Methods Symposium Georgia Salanti Statistical Methods Group Comparing Multiple Interventions Methods Group Vienna, 02nd October 2015 Trusted evidence. Informed decisions. Better health.
When do difficult situations arise? Methods to debate Use of emerging methods New developments or improvements in existing approaches are needed in some areas and apply to some CRGs (e.g. metaanalysis for sparse data) Not all are suitable for CRs or
reviews at all! Debate which Use of existing methodsone is more appropriate Is MECIR enough to address these issues? Incomplete methodological guidance Under-developped methodology MECIR tells you what you are expected to do but now how you should do it!
Handbook balances between being understandable and technically sound and cannot cover all detail. Plus, recommendations in the Handbook are not binding! What to do when disagreements arise? Framework Anarchy Driving engine for innovation Encourages peoples creativity Gives a feeling of autonomy to CRGs CGRs know best whats
appropriate for their reviews When do difficult situations arise? Flexibility in CRGs Anarchy Tyranny Aristocracy Guarantees minimum methodological standards for all reviews Safeguards against a pick-andchose approach Makes the best use of resources
many Cochrane methodologists When do difficult situations arise? Flexibility in CRGs Anarchy Democratic federation Tyranny - Aristocracy Try to find a sensible business model ....Where methods in Cochrane Reviews can be picked from a pool of
Optimal methods Appropriate methods Tolerated methods Inappropriate methods List to be established by Methods Groups in collaboration with CRGs A communication model is needed to feedback between Review Groups and the Methods Groups (e.g. prompting the Methods Groups when a new method is published, or flagging out methodological gaps link with MIF) Example: Challenges in SMG
Estimators of heterogeneity and alternative RE models Discussion in SMG mailing list (couple year ago!) attracted our attention There are different estimates of heterogeneity and alternative random effects models Concerns about Cochrane Reviews using out-of-date methods to synthesize data and draw conclusions! Example: Challenges in SMG Estimators of heterogeneity An Heterogeneity and Random Effects Task Force was created with experts from the field (included non-Cochrane researchers)
We reviewed the literature, examined simulation/empirical studies and compiled expert opinion Reached consensus and summarized it in a paper We have recommendations With our own resources This was an exceptional case Example: Challenges in Methods Groups CRGs Reviewers
Method s Groups Handbook Revman Discuss with CRGs A Democratic Federation needs: Each Methods Group needs to Review the literature
Assess the available methods for suitability for CRs Come up with the list of optimal, appropriate Optimal methods Appropriate methods and tolerated methods and no-no methods! Inform MIF for important research gaps Tolerated methods methods Devise an interim policy for methodological Inappropriate gaps
Update the list of methods regularly You cant do this with volunteers! SMG has now a part-time methodologist! We need to do this now Because prevention is always preferable to cure
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Stimulate/ follow 21 service trials or launches in Health, Automotive and Education where mobile plays a leading role (connectivity and value added services) Promote the role of mobile in the connected world
Define the specific gap in knowledge/challenge impeding further progress that your proposal will address. ... Polycistronic: a type of messenger RNA that can encode more than one polypeptide separately within the same RNA molecule. Bacterial messenger RNA is generally polycistronic.
for modifiability and reuse, factor out common services and modify them in a single location or small number of locations. for scalability and availability, centralize the control of these resources and services while distributing the resources themselves across multiple physical...