PG-Rs (prostaglandins) etc. capsaicin receptor cloned (by D.Julius & M.Caterina et al. Nature 97) (cDNA from rodent DRG injected into HEK cells, screen for >Ca 2+ fluorescence on capsaicin application) vanilloid-R1 V1
by sequence homology very similar to drosophila transient receptor potential channel TRP TRPV1 TRP receptor familyTRPVs, TRPAs, TRPMs, TRPCs TRPV1: sensitive to capsaicin, proton heat, some endocannabinoid lipids ), pH
from stimulus to impulse train transduction spike encoding Pacinian corpuscle stimulus
encoding adaptation vs. habituation vibration, texture Dynamic response of sensory receptors frequency tuning curve
SA RA Pacinian corpuscle sensitivity Hz
300 100 0 dynamic range LTM vs. nociceptor "threshold"
encoding region saturation firing frequency Intensity scaling WDR
stimulus intensity firing frequency Intensity scaling LTM nociceptor
stimulus intensity firing frequency Intensity scaling LTM
nociceptor stimulus intensity from stimulus to impulse train 1. force transmission to sensory ending 2. transduction
3. spike encoding Stimulus transmission viscoelastic properties of skin Stimulus transmission viscoelastic properties of skin hair shaft
Variety of sensory endings (to code stimulus intensity, quality, dynamics) 1. force transmission to sensory ending 2. transduction 3. spike encoding RA
SA RA Variety of sensory endings A: LTMs: SA, RA, PC, hair A: warming, cooling, down hair, mechano-nociceptors C:
mechanical nociceptors mechano-heat nociceptors CMH polymodal nociceptors silent (sleeping) nociceptors Somatosensory System and Pain
lecture 2: Sensory transduction and encoding Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem Somato-visceral sensation
Receptive Field tissue skin deep (musculoskeletal, visceral, brain) modality/ quality touch (static-dynamic (vibration, movement)) thermal chemical
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Ej. (Trapani, 2000, 2006) Citar referencias de un mismo autor/investigador Si el autor tiene más de una publicación del mismo año, se debe: añadir letras minúsculas a todos los años de publicación y los mantiene en secuencia. Ej.
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