Measuring mortality due to HIV-associated TB Verbal and
Measuring mortality due to HIV-associated TB Verbal and minimally-invasive autopsies conducted in South Africa Sanj Karat on behalf of the Lesedi Kamoso team: Mpho Tlali, Salome Charalambous, Violet Chihota, Gavin Churchyard, Yasmeen Hanifa, Suzanne Johnson, Kathleen Kahn, Neil Martinson, Kerrigan McCarthy, Tanvier Omar, Katherine Fielding, and Alison Grant Improving health worldwide www.lshtm.ac.uk Counting TB deaths 1.5 million TB deaths
390,000 among HIV-positive people 95% reduction in TB deaths by 2035 WHO (2015) Global tuberculosis report WHO (2015) The END TB strategy Background Vital registration and cause of death Glaziou et al. Technical appendix to global TB report 2015
ICD-coding of TB deaths human immunodeficiency [HIV] disease resulting in tuberculosis (B20.0) International classification of diseases (ICD), 10 th revision ICD-coding of HIV-associated TB International classification of diseases (ICD), 10 th revision HIV+ TB deaths counted as HIV International classification of diseases (ICD), 10 th revision
Modelling for mortality Estimates of mortality due to HIV-associated TB Modelling TB case-fatality ratios + Pooled research data HIV+ TB incidence
Modelling Prevalence surveys Prevalence surveys Modelling Prevalence surveys Glaziou P, et al. (2015) WHO Global TB Report 2015: Technical appendix UNAIDS (2015) Methods for deriving UNAIDS estimates
Straetemans M, et al. (2011) PLoS One 6(6): e20755 + Casenotification Tissue autopsy: the gold standard Cain 2015 Kenya 11% TB Lucas 1993 Cote dIvoire 38% TB
Nelson 1993 Zaire 41% TB Omar 2015 South Africa 32% TB Ansari 2002 Botswana 40% TB Murray 2007 South Africa 47% TB Martinson 2007
South Africa 79% TB Rana 2000 Kenya 51% TB Cox 2012 Uganda 46% TB Siika 2012 Kenya 34% TB Ngwalali 2005
Tanzania 19% TB Bates 2015 Zambia 65% TB Wong 2012 South Africa 64% TB Cohen 2010 South Africa 47% TB
Menendez 2008 Mozambique 18% TB Garcia-Jardon 2011 South Africa 51% TB Verbal autopsy: useful but limited Setting The TB Fast Track study TB Fast Track a reminder
Population 24 PHCs in semi-rural and peri-urban South Africa HIV+ adults (age 18) CD4 150 cells/lll No ART (6 months) No TB treatment (3 months) Ambulatory at enrolment Lesedi kamoso: research questions Among those who died after enrolment to TB Fast Track 1. What was the prevalence of active TB disease at autopsy? 2. What were the causes of death as assigned by clinical
methods and verbal autopsy? 3. How did verbal autopsy perform in assigning causes of death? Methods HOSPITAL Parent study Hospitals & clinics NHLS database MIA Autopsy data
Verbal autopsy Clinical and research data VA data Methods HOSPITAL Parent study Hospitals & clinics NHLS database
MIA Autopsy data Verbal autopsy Clinical and research data Clinico-pathological panel VA data PCVA Gold standard CoD Autopsy prevalence
Comparison CCVA VA CoD Demographics (n=259) Female 116/259 (55%) Median age
39 (IQR 33-46) years Median CD4 count at enrolment 44 (IQR 20-88) cells/lL Median time from enrolment to death 79 (IQR 34-170) days Death in hospital 145/259 (68%)
Median time from death to VA 140 (IQR 76-288) days Objective 1 Autopsy prevalence Those with MIA (n=34) Female 18/34 (53%) Median age
39 (IQR 33-44) years Median CD4 count at enrolment 34 (IQR 17-66) cells/lL Median time from enrolment to death 60 (IQR 21-175) days Death in hospital 25/34 (74%)
Median time from death to MIA 5 (IQR 3-6) days Autopsy prevalence (n=34) Active TB disease 16/34 (47%) Individuals with TB (n=16) Pulmonary TB 13/16 (81%) Individuals with TB (n=16) Extra pulmonary TB
14/16 (89%) Individuals with TB (n=16) EPTB only 3/16 (19%) PTB + EPTB 11/16 (69%) PTB only, 2/16 (13%) Autopsy prevalence (n=34) Active TB disease 16/34 (47%)
Other 34% VA: InterVA-4 software (ICD-10) CSMF=cause-specific mortality fraction Comparison to VA CoD (n=259) Gold standard (ICD-10) Performance of VA method (n=259) IndividualHIV/AIDS agreement 65% Cohens kappa
0.94 Other 0.76 0.75 34%0.62 VA: InterVA-4 software (ICD-10) CSMF=cause-specific mortality fraction Summary The autopsy prevalence of TB was high among individuals enrolled in the community, similar to findings from previous hospital-based studies Majority of those with TB had extrapulmonary and/lor disseminated disease Bacterial and other infections were common; several
individuals had multiple infections TB was the main cause of death in a over a quarter of decedents, but this was not clear when ICD-10 codes were used VA performed poorly in assigning individual CoD, but provided more accurate population-level estimates Recommendations A need to directly measure mortality due to HIV-associated TB Consider amendments to ICD coding of HIV deaths VA currently unsuitable for individual CoD assignment in areas of high HIV prevalence Implement MIA at sentinel sites to allow direct
estimation of TB prevalence at death Acknowledgments We owe an enormous debt to the generous individuals and their families who gave their consent and time for this study Funding The Bill and Melinda Gates Foundation Collaborators South African Department of Health: provincial and district ethics committees Clinic staff at all the TB Fast Track, XPHACTOR, and XTEND clinics Management and staff at Dilokong, Dr George Mukhari, Jane Furse, Jubilee, Mecklenberg, Odi, and Tembisa hospitals The parent study teams TB Fast Track, XPHACTOR, and XTEND
Reviewing physicians Prof Lucille Blumberg and Drs Kim Roberg, Sarah Stacey, Michelle Venter, Sarah Stacey, Evan Shoul, and Dave Spencer The Lesedi Kamoso team Bongani Nkaqa, Khethekile Ntsontso, Monde Phasha, Mphonyana Motsapi, Thabo Setimela, and Zanele Nthebe
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