Renewed Research for Patient Benefit Programme

Renewed Research for Patient Benefit Programme

Unpacking the NIHR Development, engagement, effect and opportunities Ben Morgan | Research for Patient Benefit (RfPB) funding scheme NIHR Central Coordinating Facility Helen Harris-Joseph NIHR Training Programme Kay Lakin NIHR Evaluation, Trials and Studies Coordinating Centre Saima Nayab | Invention for Innovation (i4i) funding scheme NIHR Central Coordinating Facility Julie Bayley (chair) | ARMA Impact Special Interest Group Coventry University Session About NIHR The view from within NIHR: scope, opportunities and challenges Development | academic and clinician professional skills and careers Example: the NIHR Training Programme Engagement | of patients, industry and beneficiaries

Example: the Research for Patient Benefit (RfPB) scheme Effect | benefits and impact on health, wealth and wider practice Examples: NIHR Evaluation, Trials and Studies Coordinating Centre; and the Invention for Innovation (i4i) scheme Group discussion and panel reflections www.nihr.ac.uk About NIHR VISION To improve the health and wealth of the nation through research. MISSION To provide a health research system in which the NHS supports outstanding individuals working in world-class facilities, conducting leading-edge research focused on the needs of patients and the public.

www.nihr.ac.uk NIHR Health Research System NIHR is a whole health research system designed to: - fund leading-edge scientific research - drive faster translation of science into tangible benefits for patients - create conditions for inward investment by the life-sciences sector www.nihr.ac.uk The Innovation Pathway Academic Health Science Centres www.nihr.ac.uk The Innovation Pathway INVENTION Creation

new things new ideas new techniques new approaches EVALUATION Assessment new things new ideas new techniques new approaches ADOPTION Uptake new things new ideas new techniques new approaches

DIFFUSION Spread new things new ideas new techniques new approaches Basic Research Applied Research Commissioning Patient Care MRC NIHR

CCGs NHS Providers Better Quality - Better Value www.nihr.ac.uk The Innovation Pathway INVENTION Creation Basic Research total hip replacement invented EVALUATION ADOPTION

DIFFUSION Assessment Uptake Spread Applied Research Commissioning Patient Care evidence that hip replacement is clinically and cost effective

NICE guidance on hip replacement 97,000 hip replacements performed in England in 2007/08 Effectiveness of hip prostheses in primary total hip replacement: a critical review of evidence and an economic model

www.nihr.ac.uk Research for Patient Benefit (RfPB) Programme Ben Morgan Assistant Director The RfPB Programme Response mode funding programme Supports high quality investigator-led research projects that address issues of importance to the NHS Grants may be: Costed up to 350,000 Feasibility applications costed up to 250k More upstream studies costed up to 150k Three funding competitions per year Eight Regional Advisory Panels > 750 awards made to date totalling nearly 172m Success rate of ~22% (peer reviewed applications)

www.nihr.ac.uk Ongoing Reviews Review of 125 definitive trials Review of trajectory of feasibility studies Review of tier 3 developmental/innovative research www.nihr.ac.uk Feasibility Studies Why look into an established research pathway? Push the Pace Add value in research Reduce waste Time taken for feasibility studies to progress into definitive trials appeared longer than expected (but no benchmark to compare to) What can we do to speed pathway up and increase

progression rates? www.nihr.ac.uk Feasibility Studies Join up parts of the commissioning process better, especially between programmes Help applicants/managers navigate NIHR more effectively (which programme to apply to?) Determine what evidence is needed at what stage www.nihr.ac.uk NIHR Training Programme Helen Harris-Joseph Senior Programme Manager NIHR Training Programme Research Capacity Development

NIHR provides training and career development awards in order to: build a leading healthcare research faculty develop research careers, research leaders and collaborators. Training provided through Awards programmes managed by Trainees Coordinating Centre NIHR Infrastructure: Biomedical Research Centres, Collaborations for Leadership in Applied Health Research and Care etc. Specific strategic initiatives: School for Primary Care Research www.nihr.ac.uk NIHR Research Career Paths

www.nihr.ac.uk NIHR Training Programme Research Capacity Development NIHR provides training and career development awards in order to: build a leading healthcare research faculty develop research careers, research leaders and collaborators. Training provided through Awards programmes managed by Trainees Coordinating Centre NIHR Infrastructure: Biomedical Research Centres, Collaborations for Leadership in Applied Health Research and Care etc.

Specific strategic initiatives: School for Primary Care Research www.nihr.ac.uk NIHR training awards: remit People and patient based clinical, applied health or social care research Patients, samples or data from patients, people who are not patients, populations, health technology assessment or health services research No basic research or work involving animals and/or animal tissue Biomarkers clinical evaluation not discovery Clearly demonstrate the potential to have an impact on the needs of patients and the public within 5 years of its completion NIHR is also prepared to support research into medical education www.nihr.ac.uk NIHR training awards Funding covers:

Salary Trainees have access to: Tuition fees (for PhD) Research costs Networking and community events

Full training and development programme Programme of webinars Leadership programme Mentorship programme for clinical academics Senior Awards include Research Assistant support

Indirect costs for HEIs e.g. estates, facilities at 80% @NIHR_trainees www.nihr.ac.uk NIHR Professorship Prof Nadine Foster | Musculoskeletal Health in Primary Care Professor Foster led a study which examined the implementation of stratified care in patients with low back pain - the IMPaCT Back study. In the UK, back pain accounts for 6-9% of consultations with a GP. The studys results showed that stratified care led to a reduction in the number of sickness certificates issued for back pain patients, a halving in the number of days lost from work, and improved physical function for patients. It is estimated that use of the screening tool in general practice could potentially provide savings of more than 700 million if implemented. KEY

NIHR Leadership Programme RfPB (Co) RfPB (Lead) 2007 2010 NCCRCD Primary Care Career Scientist NIHR Programme Grant (Co) MRC/EME (Co)

RfPB (Co) RfPB (Co) RfPB (Co) 2013 Senior Lectureship NIHR Other 2014 Director of Clinical Trials Unit NIHR Research Professorship NIHR Programme

Grant (Chief) National School of Primary Care HTA (Chief) HTA (Co) HTA (Chief) www.nihr.ac.uk NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) Dr Kay Lakin Research Manager Impact

NIHR NETSCC: remit NETSCC manages evaluation research programmes Hosted by the Wessex Institute at the University of Southampton Funding programmes: Efficacy and Mechanism Evaluation (EME) Health Technology Assessment (HTA) Public Health Research (PHR) Health Services and Delivery Research (HS&DR)

Systematic Reviews (SR) Commissioned and researcher-led research www.nihr.ac.uk NIHR NETSCC: remit NETSCC also manage or undertake a range of other activities: NIHR Centre for Business Intelligence Support for Clinical Trials Portfolio and Clinical Trials Units

Public Health Overview Research on Research programme Publish the NIHR Journals series: https://www.journalslibrary.nihr.ac.uk Focus on adding value in research www.nihr.ac.uk Impact assessment (NIHR-wide) Mapping the non-academic impacts of public health www.nihr.ac.uk Invention for Innovation (i4i) Saima Nayab Senior Programme Manager

i4i: Who we are, what we do NIHR translational funding scheme Support collaborative R&D and clinical adoption i4i Focus on innovative medtech solution De-risk projects for follow-on investment Patient benefit Led by Programme Director, Martin Hunt Supported by a team of Programme Managers i4i Invention for Innovation www.nihr.ac.uk i4i monitoring process

Due Diligence Impact Science scrutiny IP & Commercial scrutiny Financial scrutiny Legal scrutiny Periodic catch up on advancement and generated impact Contracting Monitoring Post-project

monitoring Enabling Delivery Progress and financial reports Milestone-based payments Site visits Research Steering Group Intellectual Property Management Group i4i Invention for Innovation www.nihr.ac.uk i4i outcomes 121 projects

>200 awarded organisations ~ 90M invested 102M funding leveraged i4i Invention for Innovation www.nihr.ac.uk Impact enablers Innovation Impact enablers

1 2 4 3 Collaborations Engagement with SMEs Route to adoption & Commercialisation i4i Invention for Innovation www.nihr.ac.uk Summary

Development Engagement Effects Academic careers Clinical professional skills and careers Patients & public Industry Clinicians Allied Health Professionals

Beneficiaries Researchers Health and wellbeing Service organisation and delivery i4i Invention for Innovation www.nihr.ac.uk Activity: discuss Development Opportunities Effect Engagement

i4i Invention for Innovation www.nihr.ac.uk Over to the panel Ben Morgan | Research for Patient Benefit (RfPB) funding scheme NIHR Central Coordinating Facility Helen Harris-Joseph NIHR Training Programme Kay Larkin NIHR Evaluation, Trials and Studies Coordinating Centre Saima Nayab | Invention for Innovation (i4i) funding scheme NIHR Central Coordinating Facility Julie Bayley | ARMA Impact Special Interest Group Coventry University www.nihr.ac.uk

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