Microbiota do corpo humano human Leonardo Sokolnik de

Microbiota do corpo humano human Leonardo Sokolnik de

Microbiota do corpo humano human Leonardo Sokolnik de Oliveira Definies Microbiota: Micro-organismos que colonizam o organismo, mas

que no produzem doena em circunstncias normais. Microbiota transitria: pode estar presente por vrios dias, meses e anos e depois desaparece. Definies Antagonismo microbiano:

Competio entre micro-organismos pelos nutrientes, onde o crescimento de um deles inibe o crescimento de outro(s). Comensalismo: Relao onde um micro-organismo beneficiado e

o outro no sofre dano ou vantagem. Mutualismo: Relao onde ambos os micro-organismos so beneficiados pela relao. Produo de vitamina K

As bactrias intestinais produzem uma parte da vitamina K, que fundamental para a produo de protenas de coagulao do sangue.

Probiticos So micro-organismos vivos que so ingeridos ou administrados para que exeram um efeito benfico sobre o organismo. Prebiticos

Ingredientes nutricionais no digerveis que afetam beneficamente o hospedeiro estimulando seletivamente o crescimento e atividade de uma ou mais bactrias benficas do clon, melhorando a sade do seu hospedeiro. Fontes: cebola, cevada, centeio, chicria, soja, alho.

Incio do estabelecimento da microbiota do corpo humano Localizao - Trato respiratrio superior - Cavidade oral - Intestinos

- Trato urinrio e genital - Pele Pele Conjuntiva ocular

Trato respiratrio superior Cavidade oral Intestino grosso Trato urinrio e reprodutivo

Micro-organismo oportunista Podem causar doena quando esto em stio anatmico diferente do normal. Exemplo: infeco urinria por Escherichia coli

Papel da microbiota intestinal na doena Diversos estudos j relacionaram a microbiota intestinal do indivduo com doenas como: obesidade, doenas circulatrias, doenas inflamatrias intestinais e at autismo. A microbiota tambm pode influenciar o

metabolismo de frmacos e o sistema imunolgico. A microbiota intestinal essencial para determinar a resposta metablica do hospedeiro aos estmulos ambientais e portanto doena. Transplante de microbiota

intestinal Estratgia para curar pacientes com diarria crnica devido infeco por Clostridium difficile aps uso de terapia antimicrobiana. Microbiota intestinal e

diabetes A presena de grande quantidade de bactrias Firmicutes aumenta a absoro de nutrientes e facilita a inflamao subclnica. Este tipo de inflamao inibe a ao da insulina, contribuindo para o diabetes melito tipo 2.

Pesquisas Pesquisas Microbiota influencia desenvolvimento do crebro Brain Behav Immun. 2017 Sep 7. pii: S0889-1591(17)30406-3. doi:

10.1016/j.bbi.2017.08.027. [Epub ahead of print] The microbiota influences cell death and microglial colonization in the perinatal mouse brain. our results suggest that direct exposure to the microbiota at birth influences key neurodevelopmental events and does so

within hours. These findings may help to explain some of the behavioral and neurochemical alterations previously seen in adult GF mice. Microbiota influencia sade da mulher e dos filhos.

Format: Abstract Send to Trends Microbiol. 2017 Aug 22. pii: S0966-842X(17)301786. doi: 10.1016/j.tim.2017.07.008. [Epub ahead of print] Women and Their Microbes: The Unexpected Friendship. Younes JA1, Lievens E2, Hummelen R3, van der Westen R 4

, Reid G5, Petrova MI6. A microbiota intestinal das crianas muda de acordo com tipo de aleitamento delas. Format: Abstract Send to

Sci Rep. 2017 Aug 21;7(1):8327. doi: 10.1038/s41598-017-08268-4. Intestinal colonisation patterns in breastfed and formula-fed infants during the first 12 weeks of life reveal sequential microbiota signatures. Timmerman HM1, Rutten NBMM2, Boekhorst J1, Saulnier DM1,3, Kortman GAM4, Contractor N5,6, Kullen M5,7, Floris E1, Harmsen HJM8, Vlieger AM2, Kleerebezem M1,9, Rijkers GT2,10.

Low abundance of potential pathogens was detected by 16S profiling and confirmed by qPCR. Incidence and dominance of skin and breast milk associated microbes were increased in the gut microbiome of breastfed infants compared to formula-fed infants

Viroma intestinal Aliment Pharmacol Ther. 2017 Sep 4. doi: 10.1111/apt.14280. [Epub ahead of print] Review article: the human intestinal virome in health and disease. The human virome consists of animal-cell viruses causing transient infections, bacteriophage (phage)

predators of bacteria and archaea, endogenous retroviruses and viruses causing persistent and latent infections

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