Serine,Alanine one Carbon Metabolism Dr. Ketki K Assistant

Serine,Alanine one Carbon Metabolism Dr. Ketki K Assistant

Serine,Alanine one Carbon Metabolism Dr. Ketki K Assistant Professor

Dept of Biochemistry HIMS Varanasi Serine

Aliphatic hydroxy amino acid Non essential Glucogenic

Sources of Serine: 1) Phosphoglycerate 2) Glycine ( glycine serine) 3) Alanine + hydroxypyruvate Pyruvate +

Serine Catabolism of serine 1) Deamination to Pyruvate

2) Transamination to hydroxypyruvate 3) Serine is glucogenic Metabolic functions of Serine

1) One carbon pool (serine glycine) 2) Formation of cysteine (homocysteine + serine homoserine + cysteine) 3) Serine alanine by dehydration & transamination

4) Phosphotidyl serine 5) Used as drug: eg, Azaserine- anticancer drug, Cycloserine- antituberculous drug

6) Choline synthesis: Serine ethanolamine choline Used for acetylcholine synthesis(Neurotransmitter),

From choline , 3 carbons can be removed, important one carbon donor (salvage pathway for one carbon unit)

7) Serine as a component of Protein a) Phosphoprotein: eg, Casein b) In covalent modification c) Glycoproteins

d) Active group of enzymes: eg: serine proteases : Trypsin,coagulation factor Alanine

Non essential Glucogenic Pyruvate + glutamate alanine + alpha keto gluterate (transamination,PLP dependant)

C/S: 1) ALT: Increased in liver disease 2) Major important participant in inter organ transport of nitrogen (glucose alanine cycle)

One carbon metabolism Content 1)

2) 3) 4)

One carbon compounds Generation of one carbon compounds Inter-conversion of one carbon compounds Utilization of one carbon compounds

One carbon metabolism Role in donating carbon atom for synthesis of several compounds

One carbon pool of the body: Generation of one carbon compounds From amino acids

1) Serine 2) Glycine 3) Histidine 4) Tryptophan

5) Choline( salvage pathway for one carbon unit) Inter-conversion of one carbon compounds

Important irreversible step: reductase Folate trap Utilization of one carbon compounds

For synthesis of 1) C2 of Purine 2) Formylation of methionyl tRNA 3) C8 of Purine

4) Glycine (glycine synthase complex) 5) Serine ( glycine to serine) 6) Choline ( ethanolamine to choline) 7) Deoxy TMP ( dUMP tp dTMP)

8) Transmethylation reactions 9) Excreted as CO2

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