LESIONS OF THE JAWS M.L. Chindia School of Dental Sciences UNIVERSITY OF NAIROBI Presentation Objectives:
1. To provide an appraisal of some common and rare jaw lesions. 2. To provide a review of the existing nomenclature 3. To stimulate some discussion on management
approaches Compound Odontoma Tiny teeth varying in number: Only afew to numerous
Do not resemble normal teeth Usually cone-shaped Histologically: Normal arrangement of a centrally placed fibrovascular pulp
Tissue surrounded by dentine Crown area covered by enamel Cementum covers the root part. Complex Odontoma Haphazard arrangement of a usually well,
delineated mass of dental hard tissues Bulk of the lesion consists of dentine Enamel plays a minor role Stroma consists of a mature fibrous connective tissue:
Sometimes contains areas identical to the Calcifying Odontogenic cyst Ghost cells maybe included Complex Odontoma
Osseous Dysplasia (OD) A pathologic process of unknown aetiology Located in the tooth bearing jaw areas Proliferation of periodontal ligament fibroblasts Bone and cementum deposition
Occurs in various clinical forms Radiographic presentation of OD Histomorphology of OD Cellular fibrous tissue
Trabeculae of woven and lamellar bone Spherules of cementum-like material Lacks encapsulation or demarcation Merges with cortical or medullary bone Tissue Variation in OD
Reflected in radiographic appearance thus: Predominantly radiolucent Predominantly radiodense Mixed Subtypes of OD
Distinguished by clinical and radiological features: Periapical Osseous Dysplasia Focal Cemento-Osseous Dysplasia occurs in the Posterior jaw quadrant is a limited lesion
Focal OD Florid Osseous Dysplasia Occurs bilaterally in the mandible or may involve all four quadrants
Non-expansile Occurs in middle-aged black females FOD Familial Gigantiform Cementoma
May involve two or more quadrants Is expansible Occurs at a young age Shows an autosomal dominant inheritance Sporadic cases reported
FGC Cementoblastoma Ossifying Fibroma (OF) A well-demacated lesion
Composed of: Fibrocellular tissue Mineralized material of varying appearances Most commonly occurs in the 2nd to 4th decates Shows a preponderance for females
Varied mean age of histological sub-types Histological Subtypes of OF Juvenile Trabecular Ossifying Fibroma (JTOF) Maxilla the site of predilection Occurs at an older age
Mitoses present at histology Less typical features: multinucleated giant cells,pseudocystic stroma degeneration,haemorrhage
Juvenile Psammomatoid Ossifying Fibroma (JPOF) Mainly occurs in the bony walls of the paranasal sinuses Occurs at a much younger age Histology shows small ossicles resembling psammoma bodies
Loose and fibrocellular to intensely cellular Minimal intervening collagen Spherical or curved ossicles Differential diagnosis: Intra cranial meningioma with psammoma bodies. The psammoma bodies in JPOF are clearly different from
the a cellular spherical true psammoma bodies Clinical appearance of OF Radiographic appearance of OF
Fibrous Dysplasia A genetically based sporadic disease of bone May affect a single (monostotic) or multiple (polyostotic) bones
FD occuring in multiple adjacent craniofacial bones is regarded as monostotic (craniofacial FD) FD may be part of the Mc Cune Albright sydrome (MAS). FD
FD Radiographic appearance of FD Ground glass appearance of FD
Radiographic appearance of FD Epeclemiology of FD The monostotic (MFD) is equally distributed in
both genders and ethnic groups The polystotic(PFD) is more frequent in females (F/M ratio;3:1) Both entities are mainly diagnosed in childhood and young adults MAS constitutes 3% of all PFD cases which may
manifest at infancy Aetiology of FD Proliferation and differentiation of preosteoblasts affected by:
Mutation in the gene (GNAS1) which encodes for the a-submit a signal transduction G-protein (Gs-alpha) Leads to increased C-AMP production Clinical Features of FD
Occurs more often in the maxilla than in the mandible May involve adjacent bones like the zygoma,sphenoid and temporal plates Base of skull and ribs are the most frequently
affected sites in the skeleton Painless swelling leading to facial asymmetry Occasionally caf, au lait pigmentation is manifest Gardeners Syndrome (GS)
Multiple polyposis of the large intestine (premalignant) Osteomas of the bones: long bones, skull and jaws Multiple epidermoid or sebeceous cysts of the
skin scalp and back Occasional occurrence of desmoid tumours Impacted supernumerary and permanent teeth Clinico-radiographic presentation
Aetiology of GS Due to a single phenotypic gene Autosommal pattern of inheritance With complete penetrance and variable expression
Osteoma A benign neoplasm Characterized by the proliferation of either compact or cancellous bone
Usually in an endosteal or periosteal location Clinical Features of Osteoma Is an uncommon oral lesion May occur at any age but more common in the
young adult Is slow growing The periosteal form of the disease manifests as a sclerotic, circumscribed mass At histology it is composed either of extremely dense compact bone or course cancellous bone.
Clinico-radiographic presentation Ameloblastic Fibroma (AF) Displays soft tissues similar to those found in an
immature tooth germ Lacks a hard tissue component Epithelial strands lie in a myxoid cell-rich mesenchyme Mitotic figures are extremely rare May contain granular cells: Granula cell AF or Granular Cell Odontogenic fibroma
Epithelial component closely resembles that of ameloblastoma The stromal component is, however, different Stroma in AF: immature,embryonic,cell rich myxoid tissue
Clinico-radiologic Features of AF Painless swelling Centrally placed: a radiolucent lesion Peripherally located: swelling in the gingivae Bone saucerization in peripheral location
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