Gynaecology SSG Sept 2015 Research Jenny Forrest, Sub

Gynaecology SSG Sept 2015 Research Jenny Forrest, Sub

Gynaecology SSG Sept 2015 Research Jenny Forrest, Sub Specialty Lead Wendy Cook, Research Delivery Manager dd/mm/yyyy Delivering clinical research to make patients, and the NHS, better Gynaecological Tumour Group National Perspective Data from Portfolio ODP Cut off 21/08/15 Gynaecological Tumour Group National Perspective 2014/2015 Network NonCommercial Commercial 2015/2016 Total NonCommercial Commercial Rank Total Rank East Midlands 12 65 77 9 1 9 10 13 Eastern 35 312 347 1 3 125 128 1 Greater Manchester 17 105 122 4 3 27 30 4 Kent, Surrey and Sussex

18 39 57 12 0 12 12 11 North East and North Cumbria 12 55 67 11 0 17 17 8 North Thames 22 104 126 3 1 20 21 5 North West Coast 10 64 74 10 1 10 11 12 North West London 12 107 119 5 3 31 34 2

South London 50 142 192 2 3 31 34 2 South West Peninsula 12 94 106 6 2 17 19 7 0 19 19 15 0 4 4 15 Wessex 15 8 23 14 5 0 5 14 West Midlands 24 59 83 8 4 11 15 10 West of England

4 51 55 13 1 15 16 9 24 79 103 7 2 18 20 6 Thames Valley and South Midlands Yorkshire and Humber Data from Portfolio ODP Cut off 21/08/15 Gynaecological Tumour Group Open Studies South West Peninsula Study Name UKCRN Study Type ID Study Design Open to New Total Sites? Recruitment DNA Methylation Study NonObservati 1449 Commercial onal Yes (LC) 211 ICON8 Trials Programme NonInterventi 9812 Commercial onal Yes 80 INTERLACE 11775 NonInterventi Commercial onal Yes 8 Data from Portfolio ODP Cut off 21/08/15 Gynaecological Tumour Group South West Peninsula Sites

2014/2015 Trust Commercial NonCommercial Northern Devon Healthcare NHS Trust 0 5 Plymouth Hospitals NHS Trust 0 Royal Cornwall Hospitals NHS Trust 2015/2016 Commercial NonCommercial 5 0 0 0 42 42 0 1 1 3 8 11 0 0 0 Royal Devon and Exeter NHS Foundation Trust 2 9 11 0 0 0 South Devon Healthcare NHS Foundation Trust 5 4 9 2 0 2 Taunton and Somerset NHS Foundation Trust 0

23 23 0 16 16 Yeovil District Hospital NHS Foundation Trust 2 3 5 0 0 0 Data from Portfolio ODP Cut off 21/08/15 Total Total Acronym UKCRN ID Study Type Trust Investigator Name End Date Target Recruitment 2015/2016 Recruitment RTT CX.5 (SHAPE):Early Stage 1A2 and 1B1 17481 Royal Cornwall Galaal, Ms NonNHS Khadra Commercial Hospitals Trust 13-Jul-22 28 0 0 -1 DESKTOP III 11498 Royal Cornwall Galaal, Ms NonNHS Khadra Commercial Hospitals Trust 31-Aug-18 2 0

0 -42 DNA Methylation Study 1449 Plymouth NonMr NHS Hughes, Commercial Hospitals Geoff Trust 31-Dec-17 20 104 1 439 DNA Methylation Study 1449 Royal Cornwall Lopes, Mr NonNHS Alberto Commercial Hospitals Trust 31-Dec-17 30 23 0 -5 DNA Methylation Study 1449 Taunton and NonSomerset NHS Milliken, Mr Commercial Foundation David Trust 01-Oct-15 15 66 16 342 GROINSS-V II 4971 Royal Cornwall Lopes, Mr NonNHS Alberto Commercial Hospitals Trust 31-Jan-17 5 0 0 -79

ICON8: Weekly Chemotherapy in Ovarian Cancer 9812 Northern NonDevon Scatchard, Dr Commercial Healthcare NHS Kate Trust 30-Nov-14 25 17 0 -54 ICON8: Weekly Chemotherapy in Ovarian Cancer 9812 Royal Cornwall NonNHS Bailey, Dr Nigel Commercial Hospitals Trust 30-Nov-14 8 11 0 120 9812 Royal Devon Nonand Exeter NHS Scatchard, Dr Commercial Foundation Kate Trust 30-Nov-14 12 27 0 54 ICON8: Weekly Chemotherapy in Ovarian Cancer Data from CRN SWP Activity Data from EDGE July 2015 Gynaecological Tumour Group South West Peninsula Open Studies Acronym UKCRN ID Study Type Trust Investigator Name End Date Target 2015/2016

Recruitment Recruitment RTT 11775 Northern NonDevon Commercial Healthcare NHS Trust Forrest , Dr Jennifer 01-Jun-16 3 4 0 58 11775 Royal Devon and Exeter NonForrest, Dr Commercial NHS Foundation Jenny Trust 01-Jun-16 9 4 0 -27 NiCCC Trial (BIBF1120) 15374 Taunton and NonSomerset NHS Barlow, Dr Commercial Foundation Clare Trust 15-Nov-19 4 0 0 -5 PETROC/OV21 7472 01-Jun-18 5 3 0 1 TRIOC 12591 01-Oct-14 5 0 0

-207 INTERLACE INTERLACE Yiannakis, Dr Plymouth NonHospitals NHS DeINTERLACE Commercial Trust nnis Plymouth NonHospitals NHS Yiannakis, Dr Commercial Trust Dennis 7 Gynaecological Tumour Group South West Peninsula Sites Data from Portfolio ODP Cut off 21/08/15 Gynaecological Tumour Group Open Studies East Midlands Study Name Eastern Total Recruitment DNA Methylation Study 34 ENGOT-EN2-DGCG-EORTC-55102 4 GROINSS-V II ICON8 Trials Programme INTERLACE NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca BriTROC1 - Sample collection study in recurrent HGSOC CORAL: Cancer of the OvaRy Abiraterone triaL Total Recruitment 28 8 CTCR-OV04 221 41 CTCR-OV05 13 67 Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) 47 DNA Methylation Study 77 GROINSS-V II 48 ICON8 Trials Programme 122 14 5 NCRN - 3244 - Masitinib +

Gemcitabine VS Gemcitabine in Ovarian Cancer 1 PARAGON 3 TRIOC: TroVax in Relapsed Ovarian Cancer 1 Data from Portfolio ODP Cut off 21/08/15 Study Name INTERLACE 1 METRO-BIBF 8 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer 1 PARAGON 8 PAZOFOS 3 Uterine LMS study 1 Gynaecological Tumour Group Open Studies Greater Manchester Study Name BriTROC1 - Sample collection study in recurrent HGSOC DNA Methylation Study GROINSS-V II ICON8 Trials Programme INTERLACE Metformin for endometrial cancer RCT METRO-BIBF MIRENA study NCRN - 2746 / ARIEL 3 Rucaparib in platinumsensitive high-grade gynaecological cancer NCRN - 3244 - Masitinib + Gemcitabine VS Gemcitabine in Ovarian Cancer PARAGON PAZOFOS TRIOC: TroVax in Relapsed Ovarian Cancer Data from Portfolio ODP Cut off 21/08/15 Total Recruitment 11 1 26 107 3 17 7 22 4 1 8 3 2 Kent, Surrey and Sussex Study Name Total Recruitment

DNA Methylation Study 33 ENGOT-EN2-DGCG-EORTC1 55102 EORTC Quality of Life Module for patients with vulva cancer GROINSS-V II ICON8 Trials Programme METRO-BIBF PARAGON TRIOC: TroVax in Relapsed Ovarian Cancer 8 12 79 4 8 5 Gynaecological Tumour Group Open Studies North Thames North East and North Cumbria Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 1 Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) 3 DNA Methylation Study 186 Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 24 DEPICT 12 DNA Methylation Study 68 GROINSS-V II 30 ICON8 Trials Programme 130 INTERLACE 22 GROINSS-V II 7 METRO-BIBF 11 ICON8 Trials Programme 72

4 1 INTERLACE 2 NCRN - 2746 / ARIEL 3 Rucaparib in platinumsensitive high-grade gynaecological cancer PARAGON 12 Uterine LMS study Data from Portfolio ODP Cut off 21/08/15 Gynaecological Tumour Group Open Studies North West London North West Coast Study Name Total Recruitment Study Name Total Recruitment 22 INTERLACE 2 MAPPING 25 METRO-BIBF 5 BriTROC1 - Sample collection study in recurrent HGSOC CANC - 3792 REFMAL 339: ME-344 with Topotecan in Solid Tumors DEPICT Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) ICON8 Trials Programme MAPPING NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 2 1 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer ProGem2 - Acelarin(NUC1031) plus Carboplatin for recurrent ovarian cancer 14 ICON8 Trials Programme NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca PARAGON TRIOC: TroVax in Relapsed Ovarian Cancer Data from Portfolio ODP Cut off 21/08/15 106 9 6

The role of obesity and diabetes in endometrial cancer BriTROC1 - Sample collection study in recurrent HGSOC 2 5 17 70 39 8 31 22 Gynaecological Tumour Group Open Studies South London Study Name ADC as a Prognostic Biomarker in Cervical Cancer BriTROC1 - Sample collection study in recurrent HGSOC CORAL: Cancer of the OvaRy Abiraterone triaL DEPICT Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) ICON8 Trials Programme MAPPING METRO-BIBF NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca Total Recruitment NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer PARAGON PAZOFOS Uterine LMS study Data from Portfolio ODP Cut off 21/08/15 95 2 Thames Valley and South Midlands 14 3 47 72 13 15 Study Name Total Recruitment ICON8 Trials Programme 35 METRO-BIBF 4 PARAGON 2 TRIOC: TroVax in Relapsed Ovarian Cancer 3 8 5 17 4 1

Gynaecological Tumour Group Open Studies West Midlands Study Name Wessex Study Name DNA Methylation Study ICON8 Trials Programme NCRN - 3244 Masitinib + Gemcitabine VS Gemcitabine in Ovarian Cancer Total Recruitment 66 23 3 BriTROC1 - Sample collection study in recurrent HGSOC DNA Methylation Study EPIVIN trial GROINSS-V II ICON8 Trials Programme INTERLACE MAPPING NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca NCRN - 3244 - Masitinib + Gemcitabine VS Gemcitabine in Ovarian Cancer PARAGON ROCkeTS Data from Portfolio ODP Cut off 21/08/15 Total Recruitment 3 1 14 25 155 4 5 5 2 2 4 Gynaecological Tumour Group Open Studies Yorkshire and Humber Study Name West of England Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 4 CORAL: Cancer of the OvaRy Abiraterone triaL 8 DNA Methylation Study 77 GROINSS-V II Total Recruitment Actinomycin-D vs Methotrexate for treatment of low risk GTN

4 BriTROC1 - Sample collection study in recurrent HGSOC 11 DNA Methylation Study 111 ENGOT-EN2-DGCG-EORTC-55102 3 GROINSS-V II 27 ICON8 Trials Programme 68 1 INTERLACE 9 ICON8 Trials Programme 80 METRO-BIBF 2 METRO-BIBF 5 NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 2 PARAGON 1 TRIOC: TroVax in Relapsed Ovarian Cancer 3 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer 3 PARAGON 5 SHAPE - Simple Hysterectomy And Pelvic node dissection in Early cervix cancer 1 Data from Portfolio ODP Cut off 21/08/15 Division 1- Cancer - Contacts Duncan Wheatley, Clinical Specialty Lead [email protected] 01872 258312 Jenny Forrest, Sub specialty lead [email protected] 01392 402106 Wendy Cook, Research delivery manager [email protected] 01392 406995 Ann Courtman, Administrator [email protected] 01392 406966 16

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