NIH HIV/AIDS Research Priorities Stacy Carrington-Lawrence Ph.D. Office

NIH HIV/AIDS Research Priorities Stacy Carrington-Lawrence Ph.D. Office

NIH HIV/AIDS Research Priorities Stacy Carrington-Lawrence Ph.D. Office of AIDS Research National Institutes of Health National Institutes of Health Office Office of of the the Director Director Office of AIDS Research National NationalInstitute Institute on onAging Aging National NationalInstitute Instituteon on

Deafness Deafnessand andOther Other Communication Communication Disorders Disorders National NationalInstitute Institute of ofGeneral General Medical MedicalScienc Sciences es National NationalInstitute Instituteof of Biomedical BiomedicalImaging Imaging and

andBioengineering Bioengineering National NationalInstitute Institute on onAlcohol AlcoholAbuse Abuse and Alcoholism and Alcoholism National NationalInstitute Institute of ofAllergy Allergyand and Infectious Diseases Infectious Diseases National NationalInstitute Institute

of Arthritis of Arthritisand and Musculoskeletal Musculoskeletal and andSkin SkinDisea Diseases ses National NationalCancer Cancer Institute Institute National NationalInstitute Institute of Child of ChildHealth Health and andHuman Human

Development Development National NationalInstitute Institute of Dental of Dentaland and Craniofacial Craniofacial Research Research National NationalInstitute Institute of Diabetes of Diabetesand and Digestive Digestiveand and Kidney KidneyDisea Diseases

ses National NationalInstitute Institute on onDrug DrugAbuse Abuse National NationalInstitute Institute of ofEnvironmental Environmental Health HealthSciences Sciences National NationalEye Eye Institute Institute National NationalHeart,

Heart, Lung, Lung,and andBlood Blood Institute Institute National NationalHuman Human Genome GenomeResearch Research Institute Institute National NationalInstitute Institute of ofMental MentalHealth Health National NationalInstitute Institute

of Neurological of Neurological Disorders Disordersand and Stroke Stroke National NationalInstitute Institute of ofNursing NursingResearch Research National NationalLibrary Library of ofMedicine Medicine National NationalCenter Centeron on

Minority Health Minority Healthand and Health HealthDisparities Disparities National NationalCenter Center for forComplementary Complementary and andIntegrative IntegrativeHealth Health John JohnE. E.Fogarty Fogarty International International Center Center

Warren WarrenGrant Grant Magnuson Magnuson Clinical ClinicalCenter Center National NationalCenter Center for forResearch Research Resources Resources Center Centerfor for Information Information Technolog Technologyy Center Centerfor

for Scientific Review Scientific Review DHHS/NIH/OD/OAR NIH HIV/AIDS Research Portfolio Largest public investment in AIDS research in the world ($3.0 Billion in FY 2016) Encompasses nearly all 27 NIH ICs Transcends every area of clinical medicine and basic scientific investigation Multi-IC, multidisciplinary, global Comprehensive program of basic, clinical, and behavioral research and training on HIV infection, associated co-infections (TB, malaria), comorbidities, and other complications NIH Overarching AIDS Research Priorities Critical to ensure that NIH AIDS funds are supporting the highest priorities for next 3-5 years: 1. Reduced incidence, including vaccines, microbicides, PrEP, TasP 2. Next generation of HIV therapies with better safety and ease of use

3. Research toward a cure 4. HIV-associated comorbidities and coinfections Cross cutting areas: Basic research, behavioral and social sciences research, health disparities, and training High Priority Research Areas For Use of AIDS Funds Reducing incidence of HIV/AIDS including: Developing/testing promising vaccines candidates, microbicide and PrEP candidates Developing and testing innovative delivery methods to mitigate adherence issues Developing, testing, and implementing strategies to improve HIV testing, entry into prevention services, and entry into treatment High Priority Research Areas For Use of AIDS Funds (continued) Next generation of HIV therapies Treatment regimens that are less toxic with fewer side effects and complications Longer acting Easier to take and adhere to than current regimens Implementation research to ensure Initiation of treatment as soon as diagnosis

has been made Retention and engagement in services Achievement and maintenance of optimal prevention and treatment responses High Priority Research Areas For Use of AIDS Funds (continued) Research toward a cure including: Developing novel approaches and strategies to identify and eliminate viral reservoirs Basic and clinical research approaches Lifelong remission of HIV infection Studies of viral persistence, latency, reactivation, and eradication HIV-associated comorbidities, coinfections, and complications including Impact of HIV-associated comorbidities, including TB, malignancies; cardiovascular, neurological, and metabolic complications Premature aging associated with long-term HIV disease and antiretroviral therapy High Priority Cross-Cutting Areas Basic research including studies on HIV transmission, pathogenesis, and immune

dysfunction Behavioral and social science research Research to reduce health disparities in incidence and treatment outcomes Training to conduct high priority research Medium-Priority Research Areas HIV/AIDS is a meaningful component of the project and/or knowledge about HIV is enhanced by the project Project addresses health and social issues clearly linked with HIV Morbidity and mortality Stigma Examines issues in the context of HIV Other infectious pathogens and diseases Non-infectious pathogens and diseases Substance use/addiction Mental health disorders Medium Priority Research Areas (continued)

Results will advance HIV treatment or prevention Results provide tools/techniques and/or capacity beneficial to HIV research Includes training and infrastructure development Innovation Realistic Aims Grantsmanship NIH Session at IAS Grantsmanship Strategies and Peer Review Workshop Wednesday, July 26 Room 241 from 16:30-18:00 NIH Turning Discovery Into Health

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