Untitled-3 [hepvu.org]

Untitled-3 [hepvu.org]

HepVu: Visualizing the Hepatitis C Epidemic Visit www.HepVu.org Subscribe to HepVus newsletter and blog updates: https://hepvu.org/email-signup/ [email protected] HepVu @HepVu HepVu.org | [email protected] | @HepVu An Introduction: HepVu and Hepatitis C in America Overview HepVu is an interactive online

resource that visualizes the Hepatitis C epidemic in the U.S. Established in 2017 to present the first standardized state-level estimates of people living with Hepatitis C HepVu is a Powered By AIDSVu project presented by the Rollins School of Public Health at Emory University in partnership with Gilead Sciences HepVu.org | [email protected] | @HepVu AIDSVu and HepVus Mission Making data widely available, easily accessible and locally

relevant to inform public health decision-making HepVu.org | [email protected] | @HepVu HepVu Advisors Co-Chair: Patrick Sullivan, Ph.D., DVM, Professor, Department of Epidemiology, Emory University, Rollins School of Public Health, and Principal Scientist, AIDSVu and HepVu Co-Chair: Ron Valdiserri, M.D., MPH, Senior Research Associate and Distinguished Scholar, Johns Hopkins University, Bloomberg School of Public Health, Former Deputy Assistant Secretary for Health, Infectious Diseases, U.S. Department of Health and Human Services Project Director: Heather Bradley, Ph.D., Assistant Professor of Epidemiology, Georgia State University HepVu Working Group Advisors:

amfAR CDC Hepatitis B Foundation Howard University Hospital Kaiser Family Foundation Massachusetts Department of Health MedStar Health Research Institute HepVu.org | [email protected] | @HepVu

NASTAD National Viral Hepatitis Roundtable NIDA Philadelphia Health Department UAB Emergency Medicine Department UCSD Eliminating Hepatitis C The public health surveillance system for Hepatitis C is not as robust as it is for other infectious diseases, such as HIV Accurate estimates of the burden of Hepatitis C infection in each state are essential to inform policy, programmatic, and resource planning for elimination strategies

HepVu is a powerful tool to communicate the Hepatitis C epidemic in a clear and compelling way to inform researchers and public health decision-makers prevention and care efforts HepVu.org | [email protected] | @HepVu Hepatitis C in America Hepatitis C is a leading cause of liver-related morbidity and mortality in America Hepatitis C-related deaths were greater than deaths from 60 other infectious diseases combined in 2013 An estimated 2.3 million people were living with Hepatitis C between 2013 and 2016 Three-fourths were Baby Boomers, or those born between 1945 and 1965

Hepatitis C and other infectious diseases are often-overlooked consequences of Americas opioid crisis Hepatitis C infections have nearly tripled in recent years, with the largest increases among persons under 40, largely due to injection drug use HepVu.org | [email protected] | @HepVu Estimation of State-level Hepatitis C Prevalence Background on Hepatitis C Prevalence Estimation State-level burden of Hepatitis C infection informs policies, resource allocation, advocacy, and

elimination efforts Prevalence of current infection (RNA) Measured in nationally representative residential survey: National Health and Nutrition Examination Survey (NHANES) In most states, it is challenging to measure directly from diagnoses reported to surveillance

Statistical models allow combining national NHANES Hepatitis C prevalence with local information to yield state-level results National Vital Statistics System (NVSS) mortality American Community Survey (ACS) population sizes HepVu.org | [email protected] | @HepVu Data published in JAMA Network Open, Dec. 2018 Overview of Analytic Approach 1 2

4 3 5 Data Sources Data source Years Purpose Number of individuals represented Number of cases

National Health and 1999-2016 National HCV RNA prevalence overall Nutrition Examination and by strata of sex, race/ethnicity, birth Survey (NHANES) cohort and poverty. Trends in anti-HCV inform analysis weights. 47,387 with non-missing HCV RNA test results 47,590 with non-missing anti-HCV test results 575 with positive HCV RNA test 874 with positive anti-HCV test U.S. Census

1999-2016 Population structure for modeling HCVintercensal data and overdose-related mortality rates. U.S. Census 2012-2016 Noninstitutionalized United States American Community population structure for final estimates. Survey (ACS) 4,109,869,228 personn/a years age 18 or above 12,023,450 observations n/a of noninstitutionalized persons aged 18 or above National Vital Statistics System (NVSS)

1999-2016 Distribution of Hepatitis C-related mortality, signaling underlying HCV prevalence, to inform distribution of older HCV infections. 44,071,310 decedents 261,858 with HCV as age 18 or above who underlying or multiple resided in the 50 states or cause of death Washington DC National Vital Statistics System (NVSS) 1999-2016 Distribution of narcotic overdose

mortality, signaling underlying injection patterns, to inform distribution of newer HCV infections. 44,071,310 decedents 541,130 with unintentional age 18 or above who or undetermined cause resided in the 50 states or narcotic or unknown drug Washington DC as cause of death HepVu.org | [email protected] | @HepVu Differences From Some Jurisdictions Data Prevalence estimates may differ from some states own internal estimates

Common approach: make adjustments to go from diagnosed cases to prevalent infections Different data sources Different methods, models, and assumptions Differences in time periods described Best estimates from national prevalence surveillance and vital statistics data State-specific methodologies not replicable in most jurisdictions with different or no case surveillance. Different assumptions required per jurisdiction Previous 2010 estimates closely mirrored local estimates in most states Primary objective: Standardized approach to allow state-to-state comparisons Some jurisdictions may have additional data to inform HCV epidemic estimates, which are valuable and should be taken into consideration for local decision-making HepVu.org | [email protected] | @HepVu

HepVu Data and Site Overview HepVu Maps View data at the statelevel, including: Hepatitis C prevalence estimates (2013-2016) Hepatitis C-related mortality data (2016) Opioid maps:

Opioid prescription rate (2017) Narcotic overdose mortality rate (2013-2016) Pain reliever misuse percent (2015-2016) HepVu.org | [email protected] | @HepVu Hepatitis C Prevalence, 2013-2016 Appalachia 3/10 highest prevalence states West 10/13 states have prevalence

above median Number of People with Hepatitis C, 2013-2016 Appalachia 5/10 states with highest number of infections TN and AZ only states in top 10 prevalence and persons with HCV 9 states comprise of 52% of all persons with Hepatitis C

Opioid Maps Narcotic Overdose Mortality Rate 2013-2016 Opioid Prescription Rate 2017 Pain Reliever Misuse Percent 2015-2016 Comparing Data View social determinants of health (poverty, high school education, etc.) alongside Hepatitis C and opioid maps

Print custom map views and develop a widget to embed the maps directly into a website HepVu.org | [email protected] | @HepVu State Profiles Click on a state to view Hepatitis C prevalence and mortality, and comparisons by region, sex, race/ethnicity, and age Use downloadable and printable graphics and charts to illustrate how states compare to others or nationally HepVu.org | [email protected] | @HepVu Deeper Look: Opioids Deeper Look: Opioids page presents an in-depth look at the opioid epidemics impact on Hepatitis C in the U.S. Page includes resources,

shareable infographics, related blogs, and a graphic illustrating the syndemic between Hepatitis C and injection drug use as a result of the opioid epidemic HepVu.org | [email protected] | @HepVu Shareable Resources and Future Research Share: Infographics on Hepatitis B and C, and the opioid syndemic Blogs from viral hepatitis and opioid experts

2019: 2013-2016 Hepatitis C prevalence estimates, stratified by race, age, and sex Additional opioid indicators Hepatitis Awareness Month and Testing Day infographics (May) Ongoing blog series with experts HepVu.org | [email protected] | @HepVu Thank you! Learn more at HepVu.org [email protected] HepVu @HepVu Subscribe to newsletter and blog updates at HepVu.org!

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