Westgard QC Rules Validator 3.0

Westgard QC Rules Validator 3.0

1 , Ali Rezvani Ph.D., Molecular Medicine Assistant Professor of Molecular Medicine at Clinical Biochemistry Department, Kermanshah University of Medical Sciences

2

QA Quality Control (QC): measures that must be included during each assay to verify that the test is working properly. Quality Control (QC) Pre-Analytical

Analytical Post-Analytical QUALITY ASSURANCE (QA) The Quality Assurance Cycle Patient/Client Prep Sample Collection Reportin

g Data and Lab Management Safety Customer Service Personnel Competency Test Evaluations

Sample Receipt and Accessioning Record Keeping Quality Control Sample Transport Testing The Quality Assurance Targets Pre analytical Process

Pat. preparation Specimen collection, Anticoagulant ,Labeling ,Storage, Transportation Analytical Process Test method/procedure, Reagant IQC,EQC Post analytical Process Review of Pat.

Results ,Posting of Pat. Results Maintenance of Pat.records Maintaining of all documents ( ( (((Test utillization

( ()Patient identification ( ( (((Turn around time ( ( ( )Patient preparation specimen collection transport specimen ( ( specimen separation aliquoting ( ( ( (

( ( ( ( ( ..... ( ( ( ( (

( ( ( ( ( ( (

( ( ( ( Drug effects on laboratory test results are difficult to take into account without an online decision support system. drug effects on laboratory tests should always be considered when interpreting

laboratory results. An online reminder system is useful in displaying potential drug effects alongside test results. Drugs often alter laboratory test results; the literature reports .40 000 drug effects on laboratory tests These effects may cause: 1-Misinterpretation of

laboratory data 2-Lead to unnecessary further tests 3-Missed diagnoses 4-Additional costs nine features Nature of effect (analytical effect, biological effect, or unknown mechanism) Route of administration Direction and strength of effect (decreasing, transient decreasing, no

effect, transient increasing,increasing effect) Level of documentation (effect has been studied with healthy volunteers and sometimes with patient) Sex of patient Age of patient Onset of effect after starting the medication Duration of effect after stopping the medication Clinical significance

Mechanisms of Interference Physical Effects: Drugs may interfere with colorimetric photometric or fluorometric analyses by imparting a characteristic color to the specimen. C h e m ic a l E f f e c t s Drugs may be measured as

analytes, either because of their similarity in chemical structure or because they contain a component that is an analyte. Pharmacological Effects This type of interference usually results from the pharmacological or toxic activity of drugs but may also arise from therapeutic quantities

of drugs. An example is the increase in prothrombin time which results from the administration of a therapeutic am ount of sodium warfarin. Thiazide diuretics and large doses of glucocorticosteroids may severely reduce the concentration of plasm a potassium.

The thiazides can also have a hyperglycemic activity Test ID: FSH Follicle-Stimulating Hormone, Serum )

( )FSH . FSH ( )E2 ( ) .

FSH ( )LH FSH LH .

) )

) ) ) )

Total estrogens, Estradiol, LH, Testosterone, Progesterone FSH

. FSH . Test ID: LH Luteinizing Hormone )LH(, Serum

LH LH . FSH LH FSH.

. LH . )Corpus (Luteum FSH LH. LH

) (E2 . LH . LH . )(Anorchia

Total estrogens, Estradiol, LH, Testosterone, Progesterone .

LH . . / LH .

. ( ) . . ( . )

LH . : LH ( Prolactin :

. ) ) ) ( ( ( ( ( (

( ( : ( ( ( ( ( ( ( ( ( ( )( ( ( ) ( ( ( ( ( ( ( . ( -

- (

) )

( ( ) ( ) Total estrogens, Estradiol, LH, Testosterone, Progesterone

( ( ( ( b- ( ( ( ( ( ) (TNF . ( .

( ( ( ( ( ( ( ( . : : (

( ( ( ( ( . ( : ( ( ( ( ) (Hook effect ( ( . ) ( ( ( ( ( ( ( ( . : :

( ) ( ( ( ( . Estradiol, 17b; 17 betaestradiol; E2 . . :

)(gynecomastia

) X ) ) ) ) (PCOS .

) ( . .

Test ID: Progesterone, Serum .

) ( -

. Fa : ) (EP .

** LH . *** LH . **** . . Total testosterone

) ( ) ) ) :(PCOS .

) ) )(PCOS

)(Anovulation ) ) ) )

) (

.

. : *** . ) (Total . :

. : FSH LH . : . Richard A. Mc Pherson, Matthew R. Pincus. Henrys Clinical Diagnosis and Management by Laboratory Method, 23rd edition, 2017, Elsevier. Carl A. Burtis, David E. Bruns. Tietz

Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th edition, 2015, Elsevier.

Recently Viewed Presentations

  • JRN 3326 Advising Student Publications -- Class II

    JRN 3326 Advising Student Publications -- Class II

    Class Notes II ... ascertain quotes, voice record, arrange to make contact later KINDS OF INTERVIEWS Electronic: If unable to reach source other ways. Written list of questions. Be professional. ... (book shelves) Tips Observe non-verbals Check some statements with...
  • Arithmetic & Geometric Sequences

    Arithmetic & Geometric Sequences

    The primary focus will be on arithmetic and geometric sequences. - Linear and exponential functions can be constructed based off a graph, a description of a relationship and an input/output table. ... is the factor between the terms (called the...
  • Development - Lower Moreland Township School District
  • Adding Vectors by the Component Method

    Adding Vectors by the Component Method

    Adding Vectors by the Component Method A = 10 km @ 60° N of E B = 25 km @ 10° N of E Final answer: 32.33 km @23.71° N of E R Adding Vectors by the Component Method Some...
  • One-Way ANOVA

    One-Way ANOVA

    Unbiasedness. Unbiasedness: The expected value (mean) of the statistic is exactly equal to the value of the parameter being estimated. The sample mean is an unbiased estimator of the population mean.
  • Principles of Marketing, Seventeenth Edition

    Principles of Marketing, Seventeenth Edition

    The Macroenvironment. Demographic Environment. Baby Boomers - born 1946 to 1964. Generation X - born between 1965 and 1976. Millennials - born between 1977 and 2000
  • Laser Safety Training Dr Katy Voisey Faculty of

    Laser Safety Training Dr Katy Voisey Faculty of

    For flux density at retina, use geometrical optics r1 r2 o i i = (r2/r1)o ≈ 200 μm o=7x108m r1= 1.5x1011m r2= 2.5x10-2m Laser hazards in context Compare with looking directly at the sun: Solar radiation flux density at the...
  • PowerPoint Sunusu

    PowerPoint Sunusu

    KOUNIN MODELİ Kounin'e göre öğretmen, sınıfın her yerinde her an ne olup bittiğini izleyecek uyanıklıkta ve hareketlilikte olmalı, iki veya daha fazla etkinliği aynı zamanda gerçekleştirebilecek bilgi, yetenek ve deneyime sahip olmalıdır.