Westgard QC Rules Validator 3.0

Westgard QC Rules Validator 3.0

1 , Ali Rezvani Ph.D., Molecular Medicine Assistant Professor of Molecular Medicine at Clinical Biochemistry Department, Kermanshah University of Medical Sciences

2

QA Quality Control (QC): measures that must be included during each assay to verify that the test is working properly. Quality Control (QC) Pre-Analytical

Analytical Post-Analytical QUALITY ASSURANCE (QA) The Quality Assurance Cycle Patient/Client Prep Sample Collection Reportin

g Data and Lab Management Safety Customer Service Personnel Competency Test Evaluations

Sample Receipt and Accessioning Record Keeping Quality Control Sample Transport Testing The Quality Assurance Targets Pre analytical Process

Pat. preparation Specimen collection, Anticoagulant ,Labeling ,Storage, Transportation Analytical Process Test method/procedure, Reagant IQC,EQC Post analytical Process Review of Pat.

Results ,Posting of Pat. Results Maintenance of Pat.records Maintaining of all documents ( ( (((Test utillization

( ()Patient identification ( ( (((Turn around time ( ( ( )Patient preparation specimen collection transport specimen ( ( specimen separation aliquoting ( ( ( (

( ( ( ( ( ..... ( ( ( ( (

( ( ( ( ( ( (

( ( ( ( Drug effects on laboratory test results are difficult to take into account without an online decision support system. drug effects on laboratory tests should always be considered when interpreting

laboratory results. An online reminder system is useful in displaying potential drug effects alongside test results. Drugs often alter laboratory test results; the literature reports .40 000 drug effects on laboratory tests These effects may cause: 1-Misinterpretation of

laboratory data 2-Lead to unnecessary further tests 3-Missed diagnoses 4-Additional costs nine features Nature of effect (analytical effect, biological effect, or unknown mechanism) Route of administration Direction and strength of effect (decreasing, transient decreasing, no

effect, transient increasing,increasing effect) Level of documentation (effect has been studied with healthy volunteers and sometimes with patient) Sex of patient Age of patient Onset of effect after starting the medication Duration of effect after stopping the medication Clinical significance

Mechanisms of Interference Physical Effects: Drugs may interfere with colorimetric photometric or fluorometric analyses by imparting a characteristic color to the specimen. C h e m ic a l E f f e c t s Drugs may be measured as

analytes, either because of their similarity in chemical structure or because they contain a component that is an analyte. Pharmacological Effects This type of interference usually results from the pharmacological or toxic activity of drugs but may also arise from therapeutic quantities

of drugs. An example is the increase in prothrombin time which results from the administration of a therapeutic am ount of sodium warfarin. Thiazide diuretics and large doses of glucocorticosteroids may severely reduce the concentration of plasm a potassium.

The thiazides can also have a hyperglycemic activity Test ID: FSH Follicle-Stimulating Hormone, Serum )

( )FSH . FSH ( )E2 ( ) .

FSH ( )LH FSH LH .

) )

) ) ) )

Total estrogens, Estradiol, LH, Testosterone, Progesterone FSH

. FSH . Test ID: LH Luteinizing Hormone )LH(, Serum

LH LH . FSH LH FSH.

. LH . )Corpus (Luteum FSH LH. LH

) (E2 . LH . LH . )(Anorchia

Total estrogens, Estradiol, LH, Testosterone, Progesterone .

LH . . / LH .

. ( ) . . ( . )

LH . : LH ( Prolactin :

. ) ) ) ( ( ( ( ( (

( ( : ( ( ( ( ( ( ( ( ( ( )( ( ( ) ( ( ( ( ( ( ( . ( -

- (

) )

( ( ) ( ) Total estrogens, Estradiol, LH, Testosterone, Progesterone

( ( ( ( b- ( ( ( ( ( ) (TNF . ( .

( ( ( ( ( ( ( ( . : : (

( ( ( ( ( . ( : ( ( ( ( ) (Hook effect ( ( . ) ( ( ( ( ( ( ( ( . : :

( ) ( ( ( ( . Estradiol, 17b; 17 betaestradiol; E2 . . :

)(gynecomastia

) X ) ) ) ) (PCOS .

) ( . .

Test ID: Progesterone, Serum .

) ( -

. Fa : ) (EP .

** LH . *** LH . **** . . Total testosterone

) ( ) ) ) :(PCOS .

) ) )(PCOS

)(Anovulation ) ) ) )

) (

.

. : *** . ) (Total . :

. : FSH LH . : . Richard A. Mc Pherson, Matthew R. Pincus. Henrys Clinical Diagnosis and Management by Laboratory Method, 23rd edition, 2017, Elsevier. Carl A. Burtis, David E. Bruns. Tietz

Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th edition, 2015, Elsevier.

Recently Viewed Presentations

  • Mechanics of Materials Engr 350 - Lecture 0

    Mechanics of Materials Engr 350 - Lecture 0

    Parallel axis theorem. States that the moment of inertia for an area about an axis is equal to the area's moment of inertia about a parallel axis passing through the centroid plus the product of the area and the square...
  • AP Rhetorical Analysis - PC\|MAC

    AP Rhetorical Analysis - PC\|MAC

    Body paragraph: Analysis of all devices and appeals in the middle of the essay. IV. Body paragraph: A discussion of the end of the essay including an analysis of the conclusion. V. Conclusion: Restate your thesis (OR bring your last...
  • CHAPTER 3 Three Claims, Four Validities: Interrogation Tools

    CHAPTER 3 Three Claims, Four Validities: Interrogation Tools

    The lecture should start with a discussion on what variables are. Then, you should continue with a discussion about the three types of claims (frequency, association, and causal) and the four validities (construct, external, statistical, and internal), and how the...
  • Constructional Profiles as the Basis of Semantic Analysis

    Constructional Profiles as the Basis of Semantic Analysis

    Constructional Profiles as the Basis of Semantic Analysis Suzanne Kemmer Rice University [email protected] Introduction Construction Grammar defines constructions as linguistic units that necessarily have some non-compositional semantics Constructions have some aspect of meaning that is not reducible to (or "predictable...
  • Determine the feasibility of converting mixed-use CII meters ...

    Determine the feasibility of converting mixed-use CII meters ...

    It is flexible, with a lot of options for improvement rather than one pass-fail calculation, e.g., 70/30. It is forward looking, applying to rates and practices that are adopted, rather than revenues received. Agency performance is not subject to external...
  • U.S. General Services Administration Federal Acquisition Service GSA/FAS

    U.S. General Services Administration Federal Acquisition Service GSA/FAS

    On the other end of the spectrum you can partner with FAS, and have the Assisted Acquisition Service manage the procurement and project for you and this is known as Full Assisted Services. Also, if you only need partial service,...
  • TESLA The car of tomorrow MOTORS By: Rachel

    TESLA The car of tomorrow MOTORS By: Rachel

    : Tesla is a much more conventional car, as the BMW has been described as narrow and small. The BMW i3 and Tesla both appeal to the luxury crowd, and in that case, the Tesla provides far better computer systems...
  • The History of Operating System - IIT-Computer Science

    The History of Operating System - IIT-Computer Science

    UNIX OS, Bell Labs (1960, portable, in C, main OS for Bell Labs) MOS home computers, 8bit. Commodore 64, Atari, Apple II Series, Spectrum 1980 (8 bit home comps) Geos, CP/M (The most successful at that time)